Dr. Raphael Kellman, the leader in microbiome medicine offers a revelatory guide to the gut-thyroid connection, with cutting-edge information and a 30-day Thyroid Rescue Program in his brand new book MICROBIOME THYROID.

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      Microbiome Thyroid Supplements

      This is a comprehensive list of supplements listed in MICROBIOME THYROID.

      This is NOT a menu of what you should be adding; please understand the context in which each supplement is recommended, and discuss them with your healthcare provider. The book MICROBIOME THYROID provides much more explanation of how these supplements work to support healthy thyroid function. The book also lists foods in which many of these substances can be found; it is always optimal to “eat your vitamins.”

      CHAPTER 3

      Glutamine: This amino acid is an excellent source of energy for immune cells. It helps support the microbiome by inhibiting the growth of compounds associated with inflammation. A study from Brazil shows that taking 30 mg of glutamine a day can make it easier to lose weight by reducing food cravings and increasing energy.

      Lipoic acid - supports glutathione production

      N-acetylcysteine (NAC) - supports glutathione production

      Slippery Elm: Slippery elm comes from the bark of the elm tree Ulmus rubra and is widely available in capsule and powder form. As its name suggests, it smooths and soothes the gut and stomach lining.

      Zinc Carnosine: Enhances mucosal defenses in the stomach and small intestine. Studies show that zinc supplementation can help tighten the junctions of the intestinal lining, helping to repair a leaky gut. When combined, these zinc and carnosine are three times stronger than when taken separately.

      Berberine: This versatile and effective supplement lowers blood sugar, improves gut function, and improves heart health. It activates AMPK, an enzyme known to regulate metabolism.

      Butyrate: A short-chain fatty acid that supports immune function and decreases gut inflammation. It improves digestion and brain function.

      Curcumin: Curcumin is the main ingredient in turmeric. It reduces intestinal inflammation and inhibits fat tissue growth.

      Omega-3 Fatty Acids: These polyunsaturated fats affect the function of cell receptors and hormone production. They decrease inflammation that can compromise thyroid function and play a protective role in cancer and heart disease.


      L. Plantarum

      • Supports intestinal distress and gut permeability
      • Improves digestion, immunity, overall health
      • Balances bacteria in the microbiome
      • Creates significant improvement in IBS (irritable bowel syndrome). Studies showed 95% saw huge improvement in all IBS symptoms vs. 5% on placebo.
      • Helps with weight loss

      L. Rhamnosus

      • Regulates insulin, leptin (satiety hormone) and ghrelin (hunger hormone)
      • Increases circulating leptin concentration, supporting appetite management
      • Research has shown that it helps with depression and executive function

      L. Acidophilus

      • Has been used to treat or prevent a wide range of ailments, including yeast infections, diarrhea, irritable bowel syndrome, lactose intolerance, intestinal problems, and urinary tract infections
      • Helps lower LDL cholesterol

      L. gasseri

      • Boosts immunity
      • Helps with allergies
      • Lowers cholesterol in combination with inulin
      • Supports weight management; helps maintain normal weight

      L. Paracasei

      • Supports respiratory and immune wellness
      • Supports the immune system through regulation of T-helper cells (T1 and T2)
      • Helps balance gut bacteria, immune system, and improve the hyperimmune state

      B. Lactis (Animalis subsp. Lactis)

      • Maintains digestive health and provides constipation relief
      • Supports the digestion of sugars, especially lactose
      • Protects the intestines from zinc deficiency; zinc is important for the formation of biomembranes (plasma membrane of epithelial cells). Zinc deficiency can lead to increased gut permeability and may also cause diarrhea
      • Enhances immunity, fights tumor growth, improves digestion, and can lower cholesterol
      • Reduces allergic responses and accompanying inflammation

      L. Helveticus

      • Improves gut health and treats gut infections
      • Helps with blood pressure, anxiety and depression
      • Improves sleep
      • Supports serum calcium in the blood by absorbing calcium from the intestines, which may provide support for strong and healthy bones

      L. lactis

      • Benefits the immune system
      • May combat allergies and hypertension
      • Increases sebum production which reinforces skin barrier

      E. Faecium (Enterococcus Faecium)

      • Produces ATP, a compound which provides energy to the cells
      • Antimicrobial benefits
      • Provides strong antiviral activity against food borne pathogens

      The following probiotics are particularly useful for decreasing inflammation:

      • Lactobacillus fermentum
      • Bifidobacterium bifidum
      • Lactobacillus rhamnosus and Lactobacillus reuteri
      • Saccharomyces boulardii
      • Bacillus coagulans
      • Lactobacillus casei

      CHAPTER 4

      Supplements proven to reduce brain inflammation include:
      Luteolin: A powerful flavonoid found in broccoli, celery and thyme. Studies show that luteolin has neuroprotective, antioxidant and anti-inflammatory effects.
      Quercetin: The pigment in brightly colored foods such as grapes, berries, citrus fruit, onions and broccoli, quercetin is the most abundant dietary flavonoid. It can reduce inflammation and blood pressure and has brain protective effects.
      Curcumin: This colorful antioxidant gives the spice turmeric its bright color and intense flavor and has powerful anti-inflammatory effects. One of the “microbiome super spices,” I recommend that you sprinkle it generously in soups, curries and salads.

      Supplements I recommend for the treatment of stress are:

      Phosphatidylserine is a phospholipid that supports the brain and helps keep the memory and mind intact. It decreases as we age. Phosphatidylserine can sometimes improve the HPA function. It can be found in soy, egg yolks, white beans and fish, but absorption from food can be inadequate and supplementation is recommended.

      Alpha Lipoic Acid: This powerful antioxidant can reduce inflammation, reduce risk of heart disease. and supports memory function. It can be found in many foods, such as spinach, broccoli, carrots, beets and red meat, but in cases of inflammation or dysfunction, I recommend supplementation.

      CHAPTER 6

      Supplements for EDC (Endocrine Disrupting Chemicals) Detox:
      Modified citrus pectin safely removes heavy metals without depleting essential minerals.
      Sulphorphane increases detoxifying enzymes in the liver.
      Activated charcoal works by binding to EDCs and preventing them from being absorbed by the digestive tract.
      Chlorella, a type of algae, has also been shown to be effective at removing toxins from the body and from preventing their absorption.
      Catalase is one of the most efficient enzymes known, and an extremely powerful liver detoxifier, especially when used in conjunction with the antioxidant glutathione.
      Probiotics have the ability to break down chemicals and toxins.

      CHAPTER 7

      Thyroid-Friendly Vitamins, Minerals, and Supplements

      Iodine is essential to make thyroid hormones. The body does not produce iodine on its own; it must be obtained through diet. I do not recommend you take an iodine supplement unless instructed by your physician, as too much of this mineral can be harmful. Similarly, don’t overdo it with iodine-rich foods either; one small portion a day should suffice.
      Selenium is a mineral that works by activating thyroid hormones so that they can be used throughout the body.
      Vitamin A helps activate thyroid hormone receptors so that hormones can enter cells to do their work. Vitamin A can also help reduce TSH levels.
      Vitamin D is technically not a vitamin, but a hormone. It helps regulate brain function, including memory and focus.
      Zinc is a trace mineral necessary in the production of thyroid hormones.
      Magnesium is one of the most abundant minerals in the body, and helps regulate many functions, including the conversion of T4 into the active form of T3.
      Omega-3 fatty acids support thyroid function by helping to create resolvins, which reduce inflammation.
      Vitamin B12 is important in thyroid function and hormone production.
      Vitamin C is a potent antioxidant that improves oxidative stress
      Glutathione is known as the “master antioxidant” as it is used by every cell in the body.

      Thyroid-Supportive Herbs

      In addition to diet and vitamin supplements, I often look to herbal supplements to support thyroid function. Herbs have been used for centuries in Chinese and Ayurvedic medical traditions. They have been shown to have many beneficial properties in health and in thyroid function in particular. Before starting any herbal supplements, discuss the use with your healthcare practitioner. Although very helpful to many, they can have negative effects if used with certain medications.

      The first four herbs on this list are adaptogens, which are non-toxic plants used to help the body resist stressors. The last, Cordyceps, is a fungus similar to a mushroom.

      • Ashwagandha has been shown to help reduce cortisol levels and balance thyroid hormones.
      • Rhodiola helps burn fat, enhance energy, and boost brain power.
      • Siberian ginseng has been shown to boost immunity.
      • Korean ginseng can help increase T3 and T4 levels.
      • Cordyceps was shown to optimize thyroid and adrenal hormone levels.

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